Exam Code: CTFL_Syll2018 Practice exam 2023 by Killexams.com team
CTFL_Syll2018 ISTQB Certified Tester Foundation Level

ISTQB has recently launched CTFL 2018 V3.1 with minor changes. You can find all the info needed in the download area.
The Foundation Level Syllabus forms the basis for the International Software Testing Qualification at the Foundation Level.
The International Software Testing Qualifications Board® (ISTQB®) provides it to the national examination bodies for them to accredit the training providers and to derive examination questions in their local language.

Training providers will produce courseware and determine appropriate teaching methods for accreditation, and the syllabus will help candidates in their preparation for the examination.

The Certified Tester Foundation Level in Software Testing
The Foundation Level qualification is aimed at anyone involved in software testing. This includes people in roles such as testers, test analysts, test engineers, test consultants, test managers, user acceptance testers and software developers.

This Foundation Level qualification is also appropriate for anyone who wants a basic understanding of software testing, such as project managers, quality managers, software development managers, business analysts, IT directors and management consultants. Holders of the Foundation Certificate will be able to go on to a higher level software testing qualification.

Fundamentals of Testing

Learning Objectives for Fundamentals of Testing:
- What is Testing?
- Identify typical objectives of testing
- Differentiate testing from debugging
- Why is Testing Necessary?
- deliver examples of why testing is necessary
- Describe the relationship between testing and quality assurance and deliver examples of how testing contributes to higher quality
- Distinguish between error, defect, and failure
- Distinguish between the root cause of a defect and its effects
- Seven Testing Principles
- Explain the seven testing principles
- Test Process
- Explain the impact of context on the test process
- Describe the test activities and respective tasks within the test process
- Differentiate the work products that support the test process
- Explain the value of maintaining traceability between the test basis and test work products
- The Psychology of Testing
- Identify the psychological factors that influence the success of testing
- Explain the difference between the mindset required for test activities and the mindset required for development activities

coverage, debugging, defect, error, failure, quality, quality assurance, root cause, test analysis, test basis, test case, test completion, test condition, test control, test data, test design, test execution, test implementation, test monitoring, test object, test objective, test oracle, test planning, test procedure, test process, test suite, testing, testware, traceability, validation, verification

Testing Throughout the Software Development Lifecycle

Learning Objectives for Testing Throughout the Software Development Lifecycle
- Software Development Lifecycle Models
- Explain the relationships between software development activities and test activities in the software development lifecycle
- Identify reasons why software development lifecycle models must be adapted to the context of project and product characteristics
- Test Levels
- Compare the different test levels from the perspective of objectives, test basis, test objects, typical defects and failures, and approaches and responsibilities
- Test Types
- Compare functional, non-functional, and white-box testing
- Recognize that functional, non-functional, and white-box tests occur at any test level
- Compare the purposes of confirmation testing and regression testing
- Maintenance Testing
- Summarize triggers for maintenance testing
- Describe the role of impact analysis in maintenance testing

acceptance testing, alpha testing, beta testing, change-related testing, commercial off-the-shelf (COTS), component integration testing, component testing, confirmation testing, contractual acceptance testing, functional testing, impact analysis, integration testing, maintenance testing, non-functional testing, operational acceptance testing, regression testing, regulatory acceptance testing, sequential development model, system integration testing, system testing, test basis, test case, test environment, test level, test object, test objective, test type, user acceptance testing, white-box testing

Static Testing

Learning Objectives for Static Testing
- Static Testing Basics
- Recognize types of software work product that can be examined by the different static testing techniques
- Use examples to describe the value of static testing
- Explain the difference between static and dynamic techniques, considering objectives, types of defects to be identified, and the role of these techniques within the software lifecycle
- Review Process
- Summarize the activities of the work product review process
- Recognize the different roles and responsibilities in a formal review
- Explain the differences between different review types: informal review, walkthrough, technical review, and inspection
- Apply a review technique to a work product to find defects
- Explain the factors that contribute to a successful review

ad hoc review, checklist-based review, dynamic testing, formal review, informal review, inspection, perspective-based reading, review, role-based review, scenario-based review, static analysis, static testing, technical review, walkthrough

Test Techniques

Learning Objectives for Test Techniques
- Categories of Test Techniques
- Explain the characteristics, commonalities, and differences between black-box test techniques, white-box test techniques, and experience-based test techniques
- Black-box Test Techniques
- Apply equivalence partitioning to derive test cases from given requirements
- Apply boundary value analysis to derive test cases from given requirements
- Apply decision table testing to derive test cases from given requirements
- Apply state transition testing to derive test cases from given requirements
- Explain how to derive test cases from a use case
- White-box Test Techniques
- Explain statement coverage
- Explain decision coverage
- Explain the value of statement and decision coverage
- Experience-based Test Techniques
- Explain error guessing
- Explain exploratory testing
- Explain checklist-based testing

black-box test technique, boundary value analysis, checklist-based testing, coverage, decision coverage, decision table testing, error guessing, equivalence partitioning, experience-based test technique, exploratory testing, state transition testing, statement coverage, test technique, use case testing, whitebox test technique

Test Management

Learning Objectives for Test Management
- Test Organization
- Explain the benefits and drawbacks of independent testing
- Identify the tasks of a test manager and tester
- Test Planning and Estimation
- Summarize the purpose and content of a test plan
- Differentiate between various test strategies
- deliver examples of potential entry and exit criteria
- Apply knowledge of prioritization, and technical and logical dependencies, to schedule test execution for a given set of test cases
- Identify factors that influence the effort related to testing
- Explain the difference between two estimation techniques: the metrics-based technique and the expert-based technique
- Test Monitoring and Control
- Recall metrics used for testing
- Summarize the purposes, contents, and audiences for test reports
- Configuration Management
- Summarize how configuration management supports testing
- Risks and Testing
- Define risk level by using likelihood and impact
- Distinguish between project and product risks
- Describe, by using examples, how product risk analysis may influence the thoroughness and scope of testing
- ement
- Write a defect report, covering a defect found during testing

configuration management, defect management, defect report, entry criteria, exit criteria, product risk, project risk, risk, risk level, risk-based testing, test approach, test control, test estimation, test manager, test monitoring, test plan, test planning, test progress report, test strategy, test summary report, tester

Tool Support for Testing

Learning Objectives for Test Tools
- Test tool considerations
- Classify test tools according to their purpose and the test activities they support
- Identify benefits and risks of test automation
- Remember special considerations for test execution and test management tools
- Effective use of tools
- Identify the main principles for selecting a tool
- Recall the objectives for using pilot projects to introduce tools
- Identify the success factors for evaluation, implementation, deployment, and on-going support of test tools in an organization

data-driven testing, keyword-driven testing, test automation, test execution tool, test management tool

ISTQB Certified Tester Foundation Level
iSQI Foundation study tips
Killexams : iSQI Foundation study tips - BingNews https://killexams.com/pass4sure/exam-detail/CTFL_Syll2018 Search results Killexams : iSQI Foundation study tips - BingNews https://killexams.com/pass4sure/exam-detail/CTFL_Syll2018 https://killexams.com/exam_list/iSQI Killexams : New Study Finds Fertility Treatments to be Safe and Effective in Women with Lupus

A recent study found assisted reproductive therapy (ART) to be safe and effective for women with lupus who have stable disease activity. ART refers to any fertility treatments in which either eggs or embryos are handled, like in vitro fertilization (IVF). While ART techniques are well-developed and widely used in the general population, their effect on women with lupus remains unclear. In this study, nearly half (46.5%) of the women became pregnant through ART, and 83.3% of the women completed their pregnancy with a successful delivery.

Researchers looked at 142 women with lupus who had an ART procedure, including ovarian stimulation, IVF, and intrauterine insemination (IUI), among others. During a nearly 10-year period, there were 72 pregnancies recorded. Infertility (the inability to conceive) occurred in 66 women. Overall, 60 pregnancies ended successfully with the delivery of 65 babies.

The risk of negative events did not increase for women who had an ART procedure compared to women with a natural, planned pregnancy. In fact, women who got pregnant from ART had fewer negative outcomes than those with natural, unplanned pregnancies. Pregnancy complications included premature delivery (birth under 37 weeks gestational age) for 21 women (31.8%), gestational diabetes reported in 15 women (22.7%), and lupus flares experienced by 10 women (15.2%).

Learn more about planning for pregnancy with lupus.

Read the study

Mon, 06 Feb 2023 10:00:00 -0600 en text/html https://www.lupus.org/news/new-study-finds-fertility-treatments-to-be-safe-and-effective-in-women-with-lupus
Killexams : Alarming new study finds half of Americans believe news organizations intend to mislead and misinform with their reporting

New York CNN  — 

America’s Frankenstein-like information environment has shattered trust.

On Wednesday, Gallup and the Knight Foundation released their annual report surveying Americans for insights into how they view the press — and the results were grim.

Only 26% of Americans hold a favorable opinion of the news media, Gallup and the Knight Foundation found — the lowest level recorded by the organizations over the last five years.

Perhaps more startling: the report found that 72% of Americans believe national newsrooms are capable of serving the public, but that they do not believe they’re well intentioned. Only 23% said that they believe national newsrooms care about the best interests of their audiences.

A version of this article first appeared in the “Reliable Sources” newsletter. Sign up for the daily digest chronicling the evolving media landscape here.

Meanwhile, Americans are having more difficulty than ever determining what to believe. 61% of respondents said the increase in information across the media landscape has made it harder to sort bad information from good.

None of this is particularly surprising, though it is, without question, alarming. The media landscape has fractured and it’s not uncommon to now see the same story presented in entirely different ways to different audiences.

Our shared reality has given way to algorithmically rendered realities. Some of the most popular media and political figures in the country actively pollute the information landscape. Many profit from propaganda that affirms the worldviews of their audiences and attacks the press in dishonest ways.

The study on Wednesday underscored this polarization. “Media trust continues to vary along predictable lines. Democrats express significantly more trust in news organizations than Republicans. Among Republicans, trust in news continues to decline,” Gallup and the Knight Foundation said.

It’s unclear how — or if — any single news organization can solve for this. MSNBC boss Rashida Jones offered her perspective on trust in media Wednesday at a New York event where she championed delivering the truth to audiences as the best path forward.

“Rather than looking at a political culture or a political perspective, what we focus on is the truth,” Jones said, outlining her editorial philosophy. “Are the angles that we’re hitting representative of truth and democracy and the rights of humans across the board? We can get stuck into both sides for a fair amount or however you look at it.”

“You can’t sacrifice the truth,” Jones continued. “Sometimes the truth isn’t pretty. Sometimes the truth might be critical of this group or that group. Rather than trying to keep a scorecard of, well, we had X number of perspectives in this party, and X number of perspectives in this party — it’s gotten a little bit more nuanced than that.”

Jones is correct. The truth isn’t pretty. And the truth can offend. What is also clear is that the truth will offend members of one political party far more than the other. That’s because the sad reality is that one party — operating in an entirely different media ecosystem largely void of fact-based journalism — tells lies and promotes misinformation at a far higher rate than the other.

Which begs the natural question: Can delivering the truth be at the heart of a news organization’s mission in 2023 if the aim is to not offend those on one end of the political spectrum at a far greater frequency than the other?

Wed, 15 Feb 2023 16:29:00 -0600 en text/html https://www.cnn.com/2023/02/15/media/gallup-knight-foundation-report-reliable-sources/index.html
Killexams : Foundation years

Return to education with our year-long introductory courses, designed to prepare you for an undergraduate degree without prior qualifications.

Our innovative courses allow you to explore your interests, whether they are in society and culture, or science and engineering. After the course, you'll be able to progress to one of our undergraduate degrees, joining a top 10 UK university (QS World University Rankings, 2023) with access to outstanding teaching and facilities.

These courses are for you if:

  • you want to study for a degree but do not have the qualifications needed to apply for other courses,
  • you have had an unconventional path in education,
  • you are interested in a subject area but are unsure what degree you would like to study.

Develop the skills and confidence to progress to an undergraduate degree, with the opportunity to find out more about subjects in the arts and social sciences, or science, engineering and mathematics.

Career prospects

On satisfactory completion of the Foundation Year in Arts and Social Sciences, you can progress to an undergraduate degree in the Faculty of Arts or the Faculty of Social Sciences and Law.

Similarly, students on the Foundation Year in Science, Engineering and Maths, can progress to a non-clinical degree within the University’s Faculty of Science, Faculty of Engineering or Faculty of Life Sciences.

We cannot certain progression to your first choice of degree as it will depend on your attainment in parts of the course, but where we cannot offer your first choice, we will do our best to offer a suitable alternative.

Both courses lead to a Certificate in Higher Education that can be used to apply for relevant undergraduate degrees or for personal or professional development.

We also offer tailored academic and personal skills development to help you prepare for degree-level study and beyond.

Course structure

You will be introduced to a range of study skills that are essential for studying a variety of subjects at undergraduate level. Both courses offer pathways for you to direct your route of study and contain mandatory and optional units depending on the pathway you choose.

For the Foundation in Arts and Social Sciences, you can choose between Arts and Humanities, Social Sciences or Economics and Finance. Classes are condensed to support students with caring and work commitments. A normal week may include two or two and a half days spent attending the University with up to eight hours of taught seminars, with a minimum of ten hours of independent study. 

For the Foundation in Science, Engineering and Technology, you can choose either a Chemistry or Physics pathway. The number of days per week spent on campus will depend on your pathway and may be spread across the week, with typically ten hours in taught seminars and an expected minimum of ten hours of independent study per week.

A welcoming and diverse community

There is no typical foundation year student. It is the diversity of prior experience, background, interests, and motivations that helps to make our foundation courses so vibrant and supportive.

Whether you left school a long time ago with few or no qualifications, spent time away from a formal career to care for family members, or are considering returning to a new field of education after spending time working in a specific industry, we are looking for people who can demonstrate their potential to succeed and who are motivated to complete the course and continue to further study.

Each application will be judged on its own merits, and we are actively looking for students from a wide range of ages and educational, ethnic, and social backgrounds.

Mon, 06 Feb 2023 09:54:00 -0600 en text/html https://www.bristol.ac.uk/study/undergraduate/foundation-years/
Killexams : Progressing to undergraduate studies from a foundation course

If you are a foundation student progressing to an undergraduate degree at Bristol, find out how to view your offer, request a change, and upload supporting documents.

Receiving your undergraduate offer

This information applies to international students who are studying:

  • International Foundation Programme (IFP) pathways at our Centre for Academic Language and Development (CALD)
  • A Bristol pathway at Kaplan International College London (KICL)
  • International Foundation Programme for Dentistry

And home students who are studying:

  • Foundation in Arts and Social Sciences
  • Foundation Year in Science, Engineering and Mathematics.

We will create your undergraduate record when you enrol as a student on your foundation programme. We will email you to let you know when your record has been created.

This email will prompt you to create an applicant portal account. You must create your account within two weeks of receiving your email, or the link will expire.

On the applicant portal you can:

  • Find the undergraduate degree course you have chosen
  • See the status of your offer (whether it is conditional or unconditional)
  • Download a copy of your offer letter
  • Upload relevant documents to your record if we request these.

Requesting a change to your undergraduate course

If you change your mind about the course you intend to join after you start your foundation studies, you can request a change.

We will do our best to accommodate change requests where this is possible. It is not always possible to change your course, for example if there are no places available, or if the content of your current course is not suitable for progression to your new choice.

Please be aware that once your change is confirmed, it may not be possible to change your course back to your original one, as your place on that course may have been offered to another student.

To request a change, follow the relevant instructions below.

CALD IFP students

Contact admissions-ifp@bristol.ac.uk to request a change. Please include your student number and the full name of your requested new course in your email.

Before you contact us, please agree the change with any relevant people who may be affected, such as:

  • Your sponsor
  • Anyone who gives you financial support for your studies
  • Your parent/guardian if you are under 18.

KICL students

Contact your college to request a change.

KICL will discuss with you whether your choice is a suitable alternative and explain any changes to progression requirements that might affect you. If they agree they can support your course change, they will inform the University on your behalf.

Uploading supporting information

We may ask you to upload additional information to support your progression.

Please do not upload any supporting documents unless we have explicitly asked you to do so. Uploading unrequested documents can lead to errors in processing your record.

Veterinary Science

Students progressing to Veterinary Science at the University of Bristol must complete a virtual work experience course via FutureLearn and a Supplementary Assessment Questionnaire (SAQ). We will email you inviting you to complete this questionnaire. Your completed SAQ must be uploaded to your applicant portal by the deadline given in this email.


Students progressing to Law courses at the University of Bristol must complete the National Aptitude Test for Law (LNAT). For more information about this test, please visit the LNAT website. We will email you to invite you to complete the test. When you have completed it, you must upload a document stating your name, student number and LNAT number by the deadline given in this email.

Visas and CAS

If you require a visa for your undergraduate studies, we may ask you to upload necessary documents for your Confirmation of Acceptance for Studies (CAS) to your applicant portal ahead of your visa application. This could be evidence of meeting English language conditions if this is not included in your IFP results, or a copy of a new passport if your original passport has an expiry date that means we cannot use it for your undergraduate visa. We will email you if we require any of these documents.

Tue, 14 Feb 2023 23:45:00 -0600 en text/html https://www.bristol.ac.uk/study/undergraduate/apply/progressing-from-a-foundation-course/
Killexams : Otumfuo Osei Tutu II Foundation: 25 students awarded sholarships to study STEM, law No result found, try new keyword!The Otumfuo Osei Tutu II Foundation has awarded scholarships to 25 brilliant but needy students to pursue various courses in tertiary institutions. Majority of the beneficiaries, are pursuing ... Wed, 08 Feb 2023 12:41:00 -0600 en-US text/html https://www.ghanaweb.com/validate_user.php?url=%2FGhanaHomePage%2FNewsArchive%2FOtumfuo-Osei-Tutu-II-F-dn-25-students-awarded-sholarships-to-study-STEM-law-1710785 Killexams : New Study by Relapsing Polychondritis Foundation Research Partners Shows VEXAS Syndrome May Be More Common Than Many Other Inflammatory Conditions

This information is from the Relapsing Polychondritis Foundation Inc. (RP Foundation) with Race for RP.

NEW YORK, Jan. 26, 2023 /PRNewswire-PRWeb/ -- A new study by investigators from the National Institutes of Health (NIH) and New York University Grossman School of Medicine (NYU Grossman), published online in the Journal of the American Medical Association (JAMA) on January 24, found that the recently discovered inflammatory disease VEXAS syndrome is more common than previously understood.

The team of researchers analyzed the health records of 163,096 adult volunteers enrolled in the Geisinger MyCode Community Health Initiative which collected data for over 25 years from a network of Pennsylvania hospitals. 12 participants, 10 men and two women, were found to have the UBA1 mutation and all exhibited VEXAS symptoms.

The findings corresponded to one in 4,269 American men over age 50 and one in 26,238 women over age 50 having or being likely to develop VEXAS, making it more common than many other inflammatory conditions, including vasculitis and myeloid dysplasia syndrome (MDS).

Study researchers plan to analyze patient records in more diverse groups, with an emphasis on patients with higher rates of rheumatologic and blood disease, to better measure VEXAS risk. They also plan to look for additional genetic causes, test new therapies, and develop a simple diagnostic blood test for the UBA1 gene, mutations in which have been identified as a cause of VEXAS.

"Philanthropic partners like the Relapsing Polychondritis Foundation are vital to this research," said geneticist and study lead investigator David B. Beck, MD, PhD. "I appreciate the foundation's support that helped get us here. We are grateful for their continued commitment to improving outcomes for people suffering from VEXAS and related autoimmune disease." Dr. Beck is an assistant professor in the Department of Medicine and the Department of Biochemistry and Molecular Pharmacology at NYU Langone Health and director of NYU Langone's clinical Inflammatory Disease Genetics Program.

Previous studies have established an overlap of clinical symptoms between VEXAS syndrome and other autoimmune disorders, with more than 50% of patients with VEXAS meeting diagnostic criteria for relapsing polychondritis (RP) and mutations in UBA1 being causal for disease in a subset of patients with RP.

The RP Foundation contributed to funding for this study and continues to invest in collaborative research, including ongoing investigations by Dr. Beck's team at NYU Grossman and the University of Texas MD Anderson Cancer Center to study the mechanisms of progression of RP to myelodysplastic syndromes and other hematological (blood-based) malignancies using genetic and transcriptomic approaches.

More information on the study can be found here.

For more information about relapsing polychondritis, the RP Foundation, and the Race for RP, please visit https://www.polychondritis.org and https://raceforrp.org. For all general and media inquiries, please contact David Bammert at (906) 869-3962 or dbammert@polychondritis.org.

About the Relapsing Polychondritis Foundation Inc. The Relapsing Polychondritis Foundation Inc. is a 501(c)(3) non-profit organization which strives to raise awareness and educate the public, as well as represent its patients to the global medical community and support medical research toward a cure. For more information about the RP Foundation, please visit the foundation's website.

About Race for RP Race for RP is a non-profit organization that supports research, awareness programs, and care, for those affected by relapsing polychondritis and related diseases. RP is a painful, debilitating, and sometimes fatal autoimmune disease in which the immune system misfires, turning on the patient's cartilage. For more information about Race for RP, please visit the organization's website.

Media Contacts:
Company Name: Relapsing Polychondritis Foundation
Name: David Bammert
Phone: (906) 869-3962
Email Address: dbammert@polychondritis.org
Website: https://www.polychondritis.org

Media Contact

David Bammert, RP Foundation, 9068693962, dbammert@polychondritis.org


SOURCE RP Foundation

© 2023 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

Thu, 26 Jan 2023 01:01:00 -0600 en text/html https://www.benzinga.com/pressreleases/23/01/n30586849/new-study-by-relapsing-polychondritis-foundation-research-partners-shows-vexas-syndrome-may-be-mor
Killexams : Study reveals early diagenetic processes of fossil land snail shells from the Chinese Loess Plateau

Terrestrial mollusks are considered as typical "index animals" due to their sensitivity to climate change. They are widely distributed in the semi-arid to arid region of China, including the Chinese Loess Plateau (CLP).

Despite the wide application of geochemical proxies of snail shells in paleoclimatic reconstruction, the extent that they were influenced by the diagenetic alteration remains unknown.

Researchers led by Associate Professor Li Tao from the Nanjing Institute of Geology and Paleontology of the Chinese Academy of Sciences (NIGPAS) and their collaborators investigated the U-series isotope geochemistry as well as the early diagenetic imprints of fossil land snail shells (Cathaica sp.) from the Mangshan loess-paleosol sequence in Henan province, central China.

They employed several geochemical techniques to investigate the mineralogy, chemical and isotopic compositions of both modern and fossil snail shells to the micrometer level.

The findings were published in Quaternary Geochronology.

"Land snail shells can be absolutely dated, and U-Th dating is a very powerful technique due to its wide age coverage (0 to 640,000 years) and solid theoretical foundation," said Li.

However, obtaining accurate U-series dates from both marine and terrestrial mollusk shells has remained challenging. A major issue is that a significant amount of U in the shell is incorporated during the diagenetic episode after the burial of the shell into the sediment.

On the CLP where fossil snail shells can be buried and isolated quickly from the influence of meteoric water due to the relatively high sedimentation rate of eolian dust and the semi-arid to the , it is possible that diagenesis might occur only in the very early stage when pore-water is still able to alter the composition and structure of the snail shells. Therefore, land snail shells on the CLP may serve as a datable archive that can be used for U-Th dating.

The Raman and SEM observations showed that the fossil shell was characterized by an elevated degree of porosity and a higher content of organic matter. The trace elemental composition of the fossil Cathaica sp. shell had also been largely reset, which is linked to the diffusion and adsorption of organic matter into the fossil shell during the early diagenetic alternation of fossil Cathaica sp. shells.

The U-series data showed that [234U/238U] and [230Th/238U] values were relatively homogeneous throughout the shell and the calculated apparent U-Th dates were within analytical error consistent with corresponding solution MC-ICPMS results, demonstrating the homogeneous distribution of [234U/238U] and [230Th/238U] within the fossil Cathaica sp. shells.

However, the apparent closed system U-Th ages of fossil Cathaica sp. shells are found to be systematically younger (~6,000 to 13,000 years) than their paired 14C ages. By evaluating possible U uptake scenarios, the researchers suggest that this apparent age discrepancy is related to the early diagenetic uptake of U and later close system behavior likely due to the isolation of fossil shells from the influence of pore waters.

More information: Tao Li et al, Early diagenetic imprints and U–Th isotope systematics of fossil land snail shells from the Chinese Loess Plateau, Quaternary Geochronology (2022). DOI: 10.1016/j.quageo.2022.101417

Citation: Study reveals early diagenetic processes of fossil land snail shells from the Chinese Loess Plateau (2023, February 10) retrieved 19 February 2023 from https://phys.org/news/2023-02-reveals-early-diagenetic-fossil-snail.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Thu, 09 Feb 2023 10:00:00 -0600 en text/html https://phys.org/news/2023-02-reveals-early-diagenetic-fossil-snail.html
Killexams : Parkinson's Foundation Global Genetics Study Hits Enrollment Milestone

PD GENEration: Mapping the Future of Parkinson's Returns Value to Participants, Physicians and Broader Research Community

NEW YORK and MIAMI, Jan. 24, 2023 /PRNewswire/ -- The Parkinson's Foundation has reached a significant milestone with the recruitment, genetic testing and counseling of 7,500 participants in its international study, PD GENEration: Mapping the Future of Parkinson's Disease. Currently at 50% of its recruitment goal of 15,000, the study includes 36 participant sites, over 50 referral sites and has expanded to Canada – while still offering home testing – as part of the Foundation's commitment to increasing access to Parkinson's disease (PD) research.

PD GENEration tests for clinically relevant genes with the goal of improving PD care by accelerating research to advance improved treatments. The study helps people with PD and their physicians identify whether they qualify for enrollment in clinical trials. Currently, investigators have found that 14% of participants have a genetic form of PD – a significant observation compared to the long-standing estimate of 10%.

"Ensuring that the entire Parkinson's community – including the 90,000 individuals expected to receive a PD diagnosis this year – has access to their genetic status is as critical as ever," said James Beck, PhD, chief scientific officer for the Parkinson's Foundation. "Every PD GENEration participant plays a part not only in their own personal discovery but also in feeding results to researchers which will advance future research."

To fully understand how PD affects individuals of diverse backgrounds, representation of the broader PD community in research is critical. Through PD GENEration, the Foundation works to increase diversity in research and aims to make no-cost genetic testing accessible to every person with PD. Participants are enrolled from all 50 U.S. states, Puerto Rico, and the Dominican Republic; and, so far, 22% of participants represent historically marginalized racial and ethnic groups.

The study continues to expand its reach with the addition of testing sites and collaborations with clinicians in historically excluded communities. The Foundation extensively engages Hispanics and Latinos and provides genetic counseling in English and Spanish, a first-of-its-kind for a study of this scale. Roughly 11% of participants identify as Hispanic, and investigators found that 17% of these individuals have a genetic link to PD – the highest rate of any ethnic group thus far.

"Through the expansion of the PD GENEration study to more populations, we are bringing diversity to genetics data," said Carlos Singer, MD, professor of neurology at the University of Miami Miller School of Medicine. "In turn, this will accelerate the pace of research to help all people with Parkinson's, regardless of where they live."

The study's data are analyzed in real-time by the Parkinson's Disease Gene Curation Expert Panel (GCEP), the first-ever genetics working group focused on neurodegenerative diseases formed by the Foundation within the NIH-funded Clinical Genome (ClinGen) Resources. The study is conducted in partnership with the Parkinson Study Group under the leadership of Michael Schwarzschild, MD, PhD, and Hubert Fernandez, MD.

To learn more about PD GENEration, visit Parkinson.org/PDGENEration or call 1-800-4PD-INFO (473-4636). For questions about enrollment, email Genetics@Parkinson.org.

About the Parkinson's Foundation

The Parkinson's Foundation makes life better for people with Parkinson's disease by improving care and advancing research toward a cure. In everything we do, we build on the energy, experience and passion of our global Parkinson's community. Since 1957, the Parkinson's Foundation has invested more than $425 million in Parkinson's research and clinical care. Connect with us on Parkinson.org, Facebook, Twitter, Instagram or call 1-800-4PD-INFO (473-4636).

About Parkinson's Disease

Affecting an estimated one million Americans and 10 million worldwide, Parkinson's disease is the second-most common neurodegenerative disease after Alzheimer's and is the 14th-leading cause of death in the U.S. It is associated with a progressive loss of motor control (e.g., shaking or tremor at rest and lack of facial expression), as well as non-motor symptoms (e.g., depression and anxiety). There is no cure for Parkinson's, and 90,000 new cases are diagnosed each year in the U.S. alone.

Marissa Cruz
Parkinson's Foundation

View original content to download multimedia:https://www.prnewswire.com/news-releases/parkinsons-foundation-global-genetics-study-hits-enrollment-milestone-301728637.html

SOURCE Parkinson's Foundation

© 2023 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

Tue, 24 Jan 2023 00:10:00 -0600 en text/html https://www.benzinga.com/pressreleases/23/01/n30546070/parkinsons-foundation-global-genetics-study-hits-enrollment-milestone
Killexams : Morris Animal Foundation Funds New Study to Advance Osteosarcoma Treatment in Dogs

DENVER, Jan. 13, 2023 /PRNewswire/ -- A new therapeutic trial hopes to change the outcomes for dogs suffering from osteosarcoma, a deadly form of bone cancer. The study, funded by Morris Animal Foundation, will be conducted by a veterinary research team at the University of Minnesota.

Morris Animal Foundation celebrates 75 years of helping animals

Led by Dr. Jessica Lawrence, Associate Professor of Radiation Oncology, the study team's goal is to test a novel immunotherapy first in the laboratory, and then in a select group of dogs with osteosarcoma to assess efficacy. If successful, the treatment could be a powerful new tool to treat osteosarcoma in dogs.

"Immunotherapy, or treatment that boosts the body's immune response against cancer, is one of the most exciting recent advances in the treatment of tumors," said Dr. Lawrence. "There are few immunotherapy options specifically for dogs; for this reason, we are incredibly grateful for support from Morris Animal Foundation to develop a new immunotherapy approach for giant-breed dogs with osteosarcoma. Osteosarcoma is good at masking itself to the body's immune system, so it can grow and spread. We hope this work will result in a new way to boost the immune system and provide hope for pet owners and oncologists faced with this terrible cancer."

Osteosarcoma is the most common primary bone tumor diagnosed in dogs. The cancer disproportionately affects the long bones of large- and giant-breed dogs. Current treatment regimens include limb amputation, chemotherapy and radiation therapy, but some dogs are poor candidates for surgery. Effective immunotherapy would be a welcome therapeutic option for these patients.

"New treatments are desperately needed for canine osteosarcoma, and immunotherapy treatments often have the advantage of fewer side effects," said Dr. Kathy Tietje, Morris Animal Foundation Vice President, Scientific Operations. "This study could help Excellerate outcomes and quality of life for dogs with osteosarcoma, particularly those that are poor surgical candidates."

Cancer impacts animals worldwide and is a leading cause of death in dogs over the age of 2. Since 1962, Morris Animal Foundation has funded more than 300 cancer studies, invested nearly $40 million, and continues to make strides against the disease.

About Morris Animal Foundation

Morris Animal Foundation's mission is to bridge science and resources to advance the health of animals. Founded in 1948 and headquartered in Denver, it is one of the largest nonprofit animal health research organizations in the world, funding more than $149 million in nearly 3,000 critical studies across a broad range of species. Learn more at morrisanimalfoundation.org.


View original content to download multimedia:https://www.prnewswire.com/news-releases/morris-animal-foundation-funds-new-study-to-advance-osteosarcoma-treatment-in-dogs-301721529.html

SOURCE Morris Animal Foundation (MAF)

Fri, 13 Jan 2023 04:03:00 -0600 en-US text/html https://finance.yahoo.com/news/morris-animal-foundation-funds-study-180000404.html
Killexams : Vitamin D supplements help pregnant women have a ‘natural delivery’, says study

omen who take extra vitamin D during their pregnancy are more likely to have a ‘natural’ delivery, according to new research.

The study, published in the Journal of Public Health, analysed results from the MAVIDOS trial which involved 965 women being randomly allocated an extra 1,000 International Units (IU) per day of vitamin D during their pregnancy or a placebo.

Analysis showed that 65.6% of women who took extra Vitamin D had a spontaneous vaginal delivery, or “natural” delivery, compared to 57.9% in the placebo group.

Fewer women from the vitamin D group had an assisted delivery (13.2%) compared with the placebo group (19.4%).

However, the number of women in each group needing a caesarean operation to deliver their baby was similar (vitamin D 21.3%, placebo 22.7%).

Dr Rebecca Moon, a clinical lecturer at the MRC Lifecourse Epidemiology Centre (MRC LEC), University of Southampton and NIHR Southampton Biomedical Research Centre, said: “Most women want to have a ‘natural delivery’ of their baby.

Vitamin D deficiency is very common in the UK. We have also shown that extra vitamin D in pregnancy can Excellerate the mother’s vitamin D level and has benefits to their child’s skeleton

“Our work suggests that taking extra vitamin D during their pregnancy might help them to achieve this.

“The women taking the extra vitamin D also had less blood loss after delivery, highlighting why this is so important. Further evidence is now needed to more thoroughly inform public health policy and clinical practice.”

MAVIDOS involved researchers from the University of Southampton and University Hospital Southampton NHS Foundation Trust (UHSFT) and is a large project looking at the benefits of vitamin D supplementation in pregnancy.

Professor Nicholas Harvey, MRC LEC deputy director and lead of MAVIDOS, said: “Vitamin D deficiency is very common in the UK. We have also shown that extra vitamin D in pregnancy can Excellerate the mother’s vitamin D level and has benefits to their child’s skeleton.

“Importantly, National Institute for Health and Care Excellence guidance recommends that all pregnant women take 400 IU vitamin D per day.”

Mon, 06 Feb 2023 16:32:00 -0600 en text/html https://www.standard.co.uk/news/health/vitamin-d-women-university-of-southampton-university-hospital-southampton-nhs-foundation-trust-national-institute-for-health-and-care-excellence-b1058304.html
CTFL_Syll2018 exam dump and training guide direct download
Training Exams List