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Exam Code: CAT-440 Practice exam 2022 by Killexams.com team CA Performance Management r2.x Professional CA-Technologies Professional study help Killexams : CA-Technologies Professional study help - BingNews
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https://killexams.com/exam_list/CA-TechnologiesKillexams : GovCon Wire
Dedrone has named Ben Wenger, a two-decade enterprise software sales veteran, as chief revenue officer and appointed Mary-Lou Smulders, strategic
Michael Barnes, former senior strategic account executive for the Department of Agriculture at Salesforce (NYSE: CRM), has joined Google's (Nasdaq:…
Mark Fabian, former strategic account executive at CA Technologies' federal business, has joined The Ambit Group as vice president of growth,…
Fri, 18 Nov 2022 10:00:00 -0600en-UStext/htmlhttps://www.govconwire.com/tag/ca-technologies/Killexams : Graduate Certificate in Professional Study
Give Your Teaching Career a Boost with a Professional Study Graduate Certificate
If you would like to advance your professional career by pursuing additional coursework beyond your degree, a Graduate Certificate of Professional Study within the field of education from Southern New Hampshire University can provide you with the opportunity to engage with a broad range of topics. Earning your graduate certificate is a great way to add to your teaching résumé while enhancing your understanding of important educational concepts and strategies.
This field-based certificate program, available through the SNHU Vermont Campus, is ideal for practicing educators seeking applied learning and professional development opportunities within the syllabu areas of curriculum, assessment and evaluation, education technology, learning and development, and teacher leadership.
Although this program is currently available in a limited number of districts within the state of Vermont, we encourage you to reach out to the SNHU Vermont Campus at firstname.lastname@example.org if you are interested in participating or learning more.
See Yourself Succeed with a Professional Study Graduate Certificate from SNHU
The field-based Professional Study Graduate Certificate program in education at SNHU allows you to choose from the following five subject areas: Curriculum, Assessment and Evaluation, Education Technology, Learning and Development, and Teacher Leadership. This is a 15-credit program, and you will select five three-credit courses to complete in accordance with your chosen topic.
As a private, nonprofit university, SNHU has one mission - to help you see yourself succeed. The benefits of enrolling in a field-based graduate program at SNHU include:
Convenience. Pursue your graduate degree or certificate where you work, and complete international field studies around your teaching schedule.
Supportive community. We have a deep understanding of how adults learn best, and we know all of our students personally. Our cohort model allows you to learn with colleagues.
Relevance. All course material and assignments apply directly to your classroom practice.
Affordability. It’s our mission to make higher education more accessible. That’s why, SNHU is one of the most affordable private, nonprofit universities in New Hampshire.
Constructivist classrooms. Our instructors design the classroom experience so that it begins with your experiences and builds toward exceptional practice in a collaborative manner.
Careers & Outcomes
The Professional Study program is designed to help educators advance their careers without committing to a full master’s degree program. The goal of this program is to produce teachers who are prepared to impact their schools and their students in meaningful ways, both inside and outside of the classroom. Whether your goal is to develop new curriculum, become familiar with new teaching technology, or learn new leadership skills, SNHU can help you take the next step in your career.
Professional Study (Post-Master's Graduate Certificate)
In addition to the standard Professional Study Graduate Certificate in education program, SNHU also offers a Professional Study Post-Master's Graduate Certificate option. This program is similar to the standard graduate certificate version, but is designed for educators who have already earned their Master of Education. This program also features Curriculum, Assessment and Evaluation, Education Technology, Learning and Development, and Teacher Leadership as subject areas; however, many of the courses within the post-master's program cover more advanced topics.
With multiple pathways to choose from, the program will help you develop a deeper understanding of responsive, responsible teaching methods. Participants will plan and deliver purposeful learning opportunities that incorporate current research and best practices to engage students in meaningful ways. SNHU will help you learn to create strengths-based, inclusive, and collaborative learning communities in classrooms and schools. The program will also help you understand the need for professional analysis, innovation, and continually evolving professional strategies while evaluating your own personal growth, teaching practice development, and personal leadership.
Our Manchester campus aims to keep tuition and related costs low for our students so that you can pursue your degree and your goals.
Beyond low tuition rates, we help our students save through transfer credits, credit for prior learning, grants and scholarships, tuition assistance and more.
This certificate is not eligible for federal financial aid. Students seeking alternatives to federal financial aid can explore tuition assistance, grants and scholarships, as well as private loans. To learn more about private loans, visit our Funding Your Education with Student Loans page.
Tue, 22 Nov 2022 10:00:00 -0600entext/htmlhttps://www.snhu.edu/campus-majors/certificates/graduate-professional-studyKillexams : Business Technology Management (BComm)
Major in Business Technology Management Minor in Computer Science
Being part of an association, not only have I gained great leadership skills, time management skills and industry knowledge, I’ve also met amazing people and had so much fun!
Sat, 24 Sep 2022 14:27:00 -0500entext/htmlhttps://www.concordia.ca/academics/undergraduate/business-technology-management.htmlKillexams : CA Southern Africa delivering ‘flow of value’ in DevOps value chain
Craig De Lucchi, Account Director, CA Southern Africa.
According to Gartner, many businesses lack end-to-end visibility, resulting in a struggle with product delivery and inability to Improve the flow of value to their markets. CA Southern Africa is exceptionally well positioned to respond to this need through its DevOps value stream that enables companies to analyse metrics and optimise the overall health of product delivery.
CA Southern Africa is the sole sub-Saharan representative of CA Technologies, a Broadcom company.
Craig De Lucchi, Account Director, CA Southern Africa, says a value chain can be defined as a set of activities that a firm operating in a specific industry performs in order to deliver a valuable product or service to the market. “This is a familiar business management concept, first described by Harvard Business Strategy Professor, Michael Porter, in his 1985 publication, Competitive Advantage: Creating and Sustaining Superior Performance.
“The CA DevOps value chain is about continuously delivering value to users/customers/consumers. CA’s DevOps pipeline enables us to stream value to our market and assist customers to raise the competitive stakes within their organisations. In an ideal state, work and information flow efficiently with minimal delays or queuing of work items,” says De Lucchi.
Today’s hyper-connected, hyper-competitive app economy moves at the speed of light. To succeed, you have no option but to continuously deliver new value to customers at the increasing pace that they demand. Your brand is now defined by the unique, and constantly evolving, digital experiences you offer to the market. These pressures mean that improving velocity and delivering optimal customer value must live at the heart of every organisation’s digital transformation strategy. As a result, businesses are transforming the way in which they design, develop and deliver applications. Their endgame is firmly focused on offering higher quality apps to customers, faster than ever before.
“In this environment, cutting-edge software development processes, such as agile methodologies and DevOps practices, have become critical to success. Agile is an iterative development process."
It taps the voice of the customer early and often, ensuring the organisation is building the right products and features and delivering them with quality and predictability. It also empowers employees by aligning their work with the strategy of the business. DevOps compounds these benefits by enhancing collaboration among the software development and IT operations teams. This accelerates and improves the process of software delivery and encourages constant collaboration. The result is more reliable releases, which ultimately help deliver an exceptional end-user experience.
Adding DevOps practices to an agile working environment improves new business growth by 63% more than using agile alone. This is revealed inColman Parkes research, which surveyed 1 770 senior business and IT executives worldwide in order to examine how enterprises are leveraging agile and DevOps within their digital transformation programmes and the impact these approaches are having on business performance.
The Coleman Parkes study found that combined, the two practices help businesses increase their organisational metabolism, allowing them to respond to changing market dynamics with speed and confidence and get to market faster. “The latter is the name of the game. CA’s accelerating tools enable huge competitive advantage to our customers that can result in a 63% improvement in new business growth and enhanced operational efficiencies,” concludes De Lucchi.
Wed, 23 Nov 2022 12:42:00 -0600entext/htmlhttps://www.itweb.co.za/content/PmxVE7KEpaQqQY85Killexams : Could trawler cams help save world's dwindling fish stocks?
By JOSHUA GOODMAN - Associated Press
PORTLAND, Maine (AP) — For years, Mark Hager’s job as an observer aboard New England fishing boats made him a marked man, seen as a meddling cop on the ocean, counting and scrutinizing every cod, haddock and flounder to enforce rules and help set crucial quotas.
On one particularly perilous voyage, he spent 12 days at sea and no crew member uttered even a single word to him.
Now Hager is working to replace such federally-mandated observers with high-definition cameras affixed to fishing boat masts. From the safety of his office, Hager uses a laptop to watch hours of footage of crew members hauling the day’s catch aboard and measuring it with long sticks marked with thick black lines. And he’s able to zoom in on every fish to verify its size and species, noting whether it is kept or flung overboard in accordance with the law.
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“Once you’ve seen hundreds of thousands of pounds of these species it becomes second nature,” said Hager as he toggled from one fish to another.
Hager’s Maine-based start-up, New England Maritime Monitoring, is one of several companies seeking to help commercial vessels comply with new U.S. mandates aimed at protecting dwindling fish stocks. It’s a brisk business as demand for sustainably caught seafood and around-the-clock monitoring has exploded from the Gulf of Alaska to the Straits of Florida.
But taking the technology overseas, where the vast majority of seafood consumed in the U.S. is caught, is a steep challenge. Only a few countries can match the U.S.′s strict regulatory oversight. And China -- the world’s biggest seafood provider with a record of illegal fishing -- appears unlikely to embrace the fishing equivalent of a police bodycam.
The result, scientists fear, could be that well-intended initiatives to replenish fish stocks and reduce unintentional bycatch of threatened species like sharks and sea turtles could backfire: By adding to the regulatory burdens already faced by America’s skippers, more fishing could be transferred overseas and further out of view of conservationists and consumers.
This story was supported by funding from the Walton Family Foundation and the Pulitzer Center on Crisis Reporting. The AP is solely responsible for all content.
“The challenge now is getting the political will,” said Jamie Gibbon, an environmental scientist at The Pew Charitable Trusts who is leading its efforts to promote electronic monitoring internationally. “We are getting close to the point where the technology is reliable enough that countries are going to have to show whether they are committed or not to transparency and responsible fisheries management.”
To many advocates, electronic monitoring is something of a silver bullet.
Since 1970, the world’s fish population has plummeted, to the point that today 35% of commercial stocks are overfished. Meanwhile, an estimated 11% of U.S. seafood imports come from illegal, unreported and unregulated fishing, according to the U.S. International Trade Commission.
To sustainably manage what’s left, scientists need reliable data on the activities of the tens of thousands of fishing vessels that ply the oceans every day, the vast majority with little supervision.
Traditional tools like captains' logbooks and dockside inspections provide limited information. Meanwhile, independent observers — a linchpin in the fight against illegal fishing — are scarce: barely 2,000 globally. In the U.S., the number of trained people willing to take underpaid jobs involving long stretches at sea in an often-dangerous fishing industry has been unable to keep pace with ever-growing demand for bait-to-plate traceability.
Even when observers are on deck, the data they collect is sometimes skewed.
“The fact is human observers are annoying,” Hager said. “Nobody wants them there, and when they aren’t being threatened or bribed, the data they provide is deeply flawed because it’s a proven fact that fishermen behave differently when they’re being watched.”
Enter electronic monitoring. For as little as $10,000, vessels can be equipped with high-resolution cameras, sensors and other technology capable of providing a safe, reliable look at what was once a giant blind spot. Some setups allow the video to be transmitted by satellite or cellular data back to shore in real time — delivering the sort of transparency that was previously unthinkable.
“This isn’t your grandfather’s fishery anymore,” said Captain Al Cottone, who recently had cameras installed on his 45-foot groundfish trawler, the Sabrina Maria. “If you’re going to sail, you just turn the cameras on and you go.”
Despite such advantages, video monitoring has been slow to catch on since its debut in the late 1990s as a pilot program to stop crab overfishing off British Columbia. Only about 1,500 of the world’s 400,000 industrial fishing vessels have installed such monitoring systems. About 600 of those vessels are in the U.S., which has been driving innovation in the field.
“We’re still in the infancy stages,” said Brett Alger, an official at NOAA charged with rolling out electronic monitoring in the U.S.
The stakes are especially high in the Western and Central Pacific Ocean — home to the world’s largest tuna fishery. Observer coverage of the Pacific’s longline fleet, which numbers around 100,000 boats, is around 2% — well below the 20% minimum threshold scientists say they need to assess a fish stock’s health. Also, observer coverage has been suspended altogether in the vast region since the start of the coronavirus pandemic, even though the roughly 1 billion hooks placed in the water each year has barely ebbed.
“Right now we’re flying blind,” said Mark Zimring, an environmental scientist for The Nature Conservancy focused on spreading video monitoring to large-scale fisheries around the world. “We don’t even have the basic science to get the rules of the game right.”
The lack of internationally-accepted protocols and technical standards has slowed progress for video monitoring, as have the high costs associated with reviewing abundant amounts of footage on shore. Hager says some of those costs will fall as machine learning and artificial intelligence — technology his company is experimenting with — ease the burden on analysts who have to sit through hours of repetitive video.
Market pressure may also spur faster adoption. Recently, Bangkok-based Thai Union, owner of the Red Lobster restaurants and Chicken of the Sea tuna brand, committed to having 100% “on-the-water” monitoring of its vast tuna supply chain by 2025. Most of that is to come from electronic monitoring.
But by far the biggest obstacle to a faster rollout internationally is the lack of political will.
Of the 13 regional fisheries management organizations in the world, only six require on-board monitoring — observers or cameras — to enforce rules on gear usage, unintentional catches and quotas, according to a 2019 study by the Paris-based Organization for Economic Cooperation and Development, which advises nations on economic policy.
Unlike in the U.S., where on-water monitoring is used to prepare stock assessments that drive policy, fisheries management in China is more primitive and enforcement of the rules spotty at best.
Last year, China deployed just two scientists to monitor a few hundred vessels that spent months fishing for squid near the Galapagos Islands. At the same time, it has blocked a widely backed proposal at the South Pacific Regional Fisheries Management Organization to boost observer requirements
“If they want to do something they definitely can,” said Yong Chen, a fisheries scientist whose lab at Stony Brook University in New York hosts regular exchanges with China. “It’s just a question of priorities.”
Many of the deaths involve observers from impoverished South Pacific islands working for low pay and with little training and support — even when placed on American-flagged vessels that are subject to federal safety regulations. Such working conditions expose observers to bribery and threats by unscrupulous captains who themselves are under pressure to make every voyage count.
“It’s in our best interest to have really professional data collection, a safe environment and lots of support from the (U.S.) government,” said Teresa Turk, a former observer who was part of a team of outside experts that in 2017 carried out a comprehensive safety review for NOAA in the aftermath of several observer fatalities.
Back in the U.S., those who make their living from commercial fishing still view cameras warily as something of a double-edged sword.
His Day Boat Seafood in 2011 became one of the first longline companies in the world to carry an ecolabel from the Marine Stewardship Council — the industry’s gold standard. As part of that sustainability drive, the Fort Pierce, Florida, company blazed a trail for video monitoring that spread throughout the U.S.’ Atlantic tuna fleet.
“I really believed in it. I thought it was a game changer,” he said.
But his enthusiasm turned when NOAA used the videos to bring civil charges against him last year for what he says was an accidental case of illegal fishing.
The bust stems from trips made by four tuna boats managed by Day Boat to a tiny fishing hole bound on all sides by the Bahamas’ exclusive economic zone and a U.S. conservation area off limits to commercial fishing. Evidence reviewed by the AP show that Taylor’s boats were fishing legally inside U.S. waters when they dropped their hooks. But hours later some of the gear, carried by hard-to-predict underwater eddies, drifted a few miles over an invisible line into Bahamian waters.
Geolocated video footage was essential to proving the government’s case, showing how the boats pulled up 48 fish — swordfish, tuna and mahi mahi — while retrieving their gear in Bahamian waters.
As a result, NOAA levied a whopping $300,000 fine that almost bankrupted Taylor’s business and has had a chilling effect up and down the East Coast’s tuna fleet.
When electronic monitoring was getting started a decade ago, it appealed to fishermen who thought that the more reliable data might help the government reopen coastal areas closed to commercial fishing since the 1980s, when the fleet was five times larger. Articles on NOAA’s website promised the technology would be used to monitor tuna stocks with greater precision, not play Big Brother.
“They had everyone snowballed,” said Martin Scanlon, a New York-based skipper who heads the Blue Water Fishermen’s Association, which represents the fleet of around 90 longline vessels. “Never once did they mention it would be used as a compliance tool.”
Meanwhile, for Taylor, his two-year fight with the federal government has cost him dearly. He’s had to lay off workers, lease out boats and can no longer afford the licensing fee for the ecolabel he worked so hard to get. Most painful of all, he’s abandoned his dream of one day passing the fishing business on to his children.
“The technology today is incredibly effective,” Taylor said. “But until foreign competitors are held to the same high standards, the only impact from all this invasiveness will be to put the American commercial fishermen out of business.”
AP Writer Caleb Jones in Honolulu, Hawaii, and Fu Ting in Washington contributed to this report.
Contact AP’s global investigative team at Investigative@ap.org. Follow Goodman on Twitter: @APJoshGoodman
Copyright 2022 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission.
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Wed, 07 Dec 2022 09:54:00 -0600entext/htmlhttps://roanoke.com/news/national/could-trawler-cams-help-save-worlds-dwindling-fish-stocks/article_bb75c6c3-09ca-5472-bfcf-a9adf875ea93.htmlKillexams : Why we need open-source science innovation — not patents and paywalls
In these research positions, professors agree to ensure all of their writing is distributed via open access — and they release all of their intellectual property in the public domain or under appropriate open-source licences.
But many academics want to see their research fully accessible — free for everyone. My research with colleagues has found the majority of American and Canadian academics want to see universities establish open-source endowed chairs.
How academics use intellectual property
Intellectual property (IP) refers to mind creations like patents and copyrights. Academics use all kind of IP. For example, professors publish their work as articles in peer-reviewed journals, the majority of which are under copyright.
If you have ever tried to read an academic paper, you probably couldn’t. Most academic papers are behind paywalls.
To gain access through the paywalls costs an enormous amount of money for a library (even Harvard’s library balked at having to pay more than US$1 million per year to access articles from a single publisher).
Accessible research in science matters because the more scientists that can read the relevant literature, the more scientists can help push innovations forward and the faster we are able to find solutions.
Many universities brag about the number of patents their professors write. Patents are supposed to encourage innovation because they deliver the inventor a 20-year monopoly to profit from an invention and this provides a financial incentive.
The basic idea is a professor would patent an invention that could be mass manufactured and then reap licence revenue for 20 years.
This is because most innovation builds on other ideas and there is no “fair use” for patents.
It is illegal to even experiment on a patented idea without a licence. If you need to wait 20 years to build on a good idea, it obviously takes a lot of time to innovate. Historically innovation moved rather slowly, now the rate of innovation is fast. Consider now how ancient a 20-year-old phone would be in your pocket.
Some academics like science and engineering professors do make money on patents for their universities. But the patent revenue they keep tends to be meager, because the costs to get the patent must first be recovered before the inventors get anything.
Open source is a better way
Open source is the answer to speeding up innovation. Open source originally was developed in the software industry as inventors would share the source code of computer programs to innovate faster.
Open source works amazingly well because having a lot of people work on a problem together tends to get a much better solution than a few.
In both these studies, we presented participants with information about open-source endowed professorships to provide context and clarity for the subsequent multiple-choice and open-ended questions.
We looked at professors in every stage of their career (assistant to emeritus), tenured and non-tenured, at all types of universities (colleges to institutions with very high research activity), and in all disciplines including professional programs.
We analyzed results for three core disciplines of engineering/technology, natural sciences and social sciences to assess if there are differences in preferred compensation types among scholars of various disciplines.
The will to share was robust across all variables. Professors as a whole would be willing to make all of their IP freely available in exchange for the open-source endowed chair.
I currently hold the John M. Thompson Chair in Information Technology and Innovation, and am one of the first endowed chairs to make an open-source commitment.
It is clear, even from my own work that has been sped along by many others freely contributing to my open-source projects, that science will move faster with open-source methods.
There is a clear willingness of academics to leave behind antiquated IP models for the good of science and society. It is time to provide incentives to accelerate innovation using open science to hasten scientific progress while also making science more just and inclusive.
All research funders — governments, foundations, private companies, donors and universities — should start funding open-source endowed chairs to maximize the impact of their resources.
Professor Joshua M. Pearce has received funding from the Natural Sciences and Engineering Research Council of Canada, MITACS, The Canada Foundation for Innovation, the Air Force Research Laboratory (ARFL) through America Makes: The National Additive Manufacturing Innovation Institute, which is managed and operated by the National Center for Defense Manufacturing and Machining (NCDMM), the U.S. Defense Advanced Research Projects Agency (DARPA), the U.S. Department of Energy (DOE) and the Advanced Research Projects Agency-Energy (ARPA-E), and the National Science Foundation (NSF) for open source related projects. In addition, his past and present research is supported by many non-profits and for-profit companies in the open source arena including ALLFED, Mosaic Manufacturing, Heliolytics, BeeHex, Glia, re:3D, Miller, Aleph Objects, Lulzbot, Virtual Foundry, Ultimaker and Youmagine, Cheap 3D Filaments, MyMiniFactory, Zeni Kinetic, Matter Hackers, and Ultimachine. He is the editor-in-chief of HardwareX, the first journal dedicated to open source scientific hardware and the author of the Open-Source Lab:How to Build Your Own Hardware and Reduce Research Costs, Create, Share, and Save Money Using Open-Source Projects, and To Catch the Sun, an open source book of inspiring stories of communities coming together to harness their own solar energy, and how you can do it too.
Mon, 05 Dec 2022 06:27:00 -0600en-CAtext/htmlhttps://ca.news.yahoo.com/why-open-source-science-innovation-202758893.htmlKillexams : Laser Photonics Chosen for Vocational Laser Program at San Bernardino Community College
Purchase of CleanTech Handheld 1000-Watt Laser System Offers Students New Technical Training Opportunities
ORLANDO, FL / ACCESSWIRE / December 1, 2022 / Laser Photonics Corporation (NASDAQ:LASE), ("LPC"), a leading global developer of CleanTech laser systems for laser cleaning and other materials applications, today announced it received an order from San Bernadino Community College, in San Bernardino, CA.
Wayne Tupuola, chief executive officer of Laser Photonics, commented: "Laser Photonics is honored to have its pioneering CleanTech laser technology chosen for vocational training at San Bernardino Community College. As part of its work-study program for laser technicians, our technology will help teach students how to use lasers in industrial applications.
"The acquisition of this system is an example of the college's commitment to expanding vocational opportunities within industry. Our CleanTech Handheld 1000-watt system was the perfect solution to fulfill the school's request for a product that met California's strict EPA laws while being safe, efficient, reliable and cost-efficient. We expect to deliver a world-class experience to students as they learn their craft on our state-of-the-art technology, after which they can bring their experience with our products into the real world."
The CleanTech™ Handheld LPC-1000CTH is a high-performance, industrial-grade 1000-watt handheld laser cleaner. This fast, precise and incredibly productive tool is a super-compact, professional-level laser cleaning and surface treatment system for medium-sized areas requiring delicate cleaning, de-painting, and other surface preparation operations. The system can also be coupled with industrial robots and placed inside safety work cells with interlocks for full compliance with OSHA and FDA CDRH as Class IV Laser Systems.
This press release contains "forward-looking statements" (within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended), including statements regarding the Company's plans, prospects, potential results and use of proceeds. These statements are based on current expectations as of the date of this press release and involve a number of risks and uncertainties, which may cause results and uses of proceeds to differ materially from those indicated by these forward-looking statements. These risks include, without limitation, those described under the caption "Risk Factors" in the Registration Statement. Any reader of this press release is cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. The Company undertakes no obligation to revise or update any forward-looking statements to reflect events or circumstances after the date of this press release except as required by applicable laws or regulations.
About Laser Photonics Corporation
Laser Photonics is a vertically-integrated manufacturer and R&D Center of Excellence for industrial laser technologies and systems. LPC seeks to disrupt the $46 billion, centuries old, sand and abrasives blasting markets, focusing on surface cleaning, rust removal, corrosion control, de-painting and other laser-based industrial applications. LPC's new generation of leading-edge laser blasting technologies and equipment also addresses the numerous health, safety, environmental, and regulatory issues associated with the old methods. As a result, LPC has quickly gained a reputation as an industry leader for industrial laser systems with a brand that stands for quality, technology and product innovation. Currently, world-renowned and Fortune 1000 manufacturers in the aerospace, automotive, defense, energy, industrial, maritime, space exploration and shipbuilding industries are using LPC's "unique-to-industry" systems. For more information, visit www.laserphotonics.com.
Wed, 30 Nov 2022 22:39:00 -0600en-UStext/htmlhttps://finance.yahoo.com/news/laser-photonics-chosen-vocational-laser-120000476.htmlKillexams : New mRNA vaccine targeting all known flu strains shows early promise
A new mRNA vaccine targeting all known flu strains in a single shot is showing early promise in animal studies and is opening the door to a wide range of possibilities with the vaccine technology — including potentially preventing the next influenza pandemic.
University of Pennsylvania researchers published their findings in the journal Science Thursday, showing the vaccine produced high levels of antibody protection in mice and ferrets against all flu strains, which could one day help pave the way for a universal flu shot.
The research rapidly lifts mRNA technology to new heights and builds off the progress made in the COVID-19 pandemic in accelerating the development of the new vaccine platform, which has already been effectively used in billions of people worldwide.
"Our approach was to make a vaccine that encoded every influenza subtype and lineage that we know about," said Scott Hensley, an immunologist at the University of Pennsylvania in Philadelphia and one of the lead authors of the study.
"The goal was to establish a baseline level of immune memory that could then be recalled when a new pandemic strain emerges."
Unlike seasonal flu shots that protect against existing circulating strains each year but offer little protection against strains that can spill over from animals and spark pandemics, like H1N1 in 2009, this shot could theoretically provide immunity against all new flu strains.
"We're still in preclinical testing at this phase, we are planning a Phase 1 human study, but so far from animal models it does look like this vaccine achieved our goal of inducing immune memory in a broad way," Hensley said.
"Imagine if the population was primed with this vaccine, what we might see is not necessarily protection from infection with new pandemic strains but a reduction in hospitalizations and severe disease — and that's really our main goal."
While a potential vaccine could be years away since it still needs to successfully undergo human trials, developing a flu shot that can target all 20 known influenza A and B strains is an astonishing scientific feat.
"It really shows that we can use mRNA vaccines in ways that we really hadn't thought of before," said Alyson Kelvin, a virologist at the University of Saskatchewan's Vaccine and Infectious Disease Organization who co-wrote an independent perspective on the study in Science.
"This is just the beginning of where we can take mRNA-based vaccines."
The research opens up a world of new possibilities with mRNA vaccine technology.
And it also brings hope of one day preventing hundreds of thousands of hospitalizations and deaths from the flu globally each year — if it passes clinical trials and regulatory approval.
"This is a way to cover a huge family of viruses that causes a large burden of disease each year around the world," Kelvin said. "As well, there's continual threats of a new influenza virus spilling over. So it could not only cover what we're currently dealing with, but what we don't know."
There are still key unanswered questions about the research and development of the vaccine to ensure it's safe and effective in clinical trials, Kelvin said, but the fact that animals were able to elicit strong and distinct immune responses to each strain is very promising.
"It really puts this strategy more than a foot in the door — I'd say completely through the door — of clinical application," said Gary Kobinger, the director of the Galveston National Laboratory at the University of Texas who helped develop a Canadian-led Ebola vaccine.
"It's one of those times where you see a scientific paper in animals and you know that this could be in humans in what would be a short-to-mid-term timeline," he added. "So let's see if this works. We all hope it will."
The vaccine uses lipid nanoparticles, a successful delivery system for mRNA vaccines developed by Canadian scientist Pieter Cullis and researchers at the University of British Columbia, to target all known flu strains that perpetually circulate and infect us each year.
WATCH | Harnessing mRNA vaccine potential:
The ground-breaking technology used to create the Pfizer and Moderna COVID-19 vaccines, mRNA, could also be used to produce vaccines for other diseases including HIV, the flu and even cancer.
"The vaccine induces broad immunity in mice and ferrets who had never seen the virus before. That mimics how this vaccine might perform in young children," Hensley said.
"But we found that the vaccine can also induce these broad responses in animals who had already experienced and recovered from a flu infection."
That means if the vaccine were proven to be safe and effective in humans and successfully approved, it wouldn't just be limited in use among children who have never before had a flu infection. It could also be used widely in the general population — including in seniors who are often at a higher risk of serious complications.
"I think we can expect to see vaccine developers going in all sorts of directions," Kelvin said. "I can't predict what those will be, but the sky's the limit of what will be done in the next couple of years."
Hensley said the researchers were unsure if the platform would even work in animals, given that potential issues can arise with what are called immunodominance hierarchies — where our immune systems react to certain strains more efficiently than others.
"We didn't find that, we found that this vaccine elicited antibodies at fairly equal levels to all of the antigens encoded," he said. "So that was an important finding."
The fact that strong antibody immune responses were shown against all 20 different flu strains is very encouraging, Kelvin said, because even if the strains don't all circulate at once, there is potential for flu strains to spill over from animals and drive a pandemic at any time.
"We know that there will be another spillover of an influenza virus with pandemic potential," she said. "Do we keep this vaccine on the shelf ready to go? Or is this something that we want to consider licensing for more seasonal approaches?"
However, there are major regulatory hurdles in approving a vaccine this complex and wide-ranging — even if it does pass clinical trials.
"The biggest question is, how do we get this into people? Because what's incorporated in the vaccine are targets for viruses that aren't currently circulating in people," Kelvin said.
"So when regulatory agencies look at how they're going to evaluate a vaccine and approve it in human use, they want to make sure that it's safe and effective. Well, what is the effectiveness that we're going to say for this vaccine?"
And while traditional flu vaccines are already effective at preventing severe illness and death in the most vulnerable when successfully matched against circulating strains — widespread uptake of the flu shot remains a major challenge.
WATCH | Flu and an overburdened health-care system:
The Ontario Medical Association is urging people to wear masks indoors and get their flu and COVID-19 shots as concern builds that a spike in flu cases could overwhelm a health-care system already seeing an influx of RSV and COVID patients.
Less than 40 per cent of Canadians opted to get a flu shot in 2020, according to the most accurate federal data, despite being recommended and available for everyone older than six months old. In the U.S., that number is somewhat higher at more than 50 per cent.
"This is the reality," Kobinger said. "You can have the best vaccine on the planet, but if nobody wants it or takes it then it's useless."
Thu, 01 Dec 2022 22:51:00 -0600entext/htmlhttps://www.cbc.ca/news/health/mrna-flu-vaccine-study-influenza-pandemic-universal-flu-shot-1.6662809Killexams : Rats 'Beat It' to the music just like humans, a study discovers
Researchers at the University of Tokyo have discovered that rats can synchronize their head movements with the beat of a song.
Keeping the rhythm to music was long thought to be a uniquely human trait. Other animals react to music or can be trained to respond to it -- as seen in online videos of dancing birds, for example -- but this is not the same as the ability to recognize a beat, the study published in Science Advances reads.
To test if rats could move with the beat, the study primarily focused on the animals’ ability to groove to Mozart's Sonata for Two Pianos in D Major, K. 448.
“Rats displayed innate — that is, without any training or prior exposure to music — beat synchronization most distinctly within 120-140 bpm (beats per minute), to which humans also exhibit the clearest beat synchronization,” Hirokazu Takahashi, associate professor at the University of Tokyo’s graduate school of information science and technology, said in a press release.
Accurately moving to a song depends on the speed at which the brain can respond to something.
"This new discovery offers not only further insight into the animal mind, but also into the origins of our own music and dance," the study said.
Using specialized head sensors, researchers could determine even the smallest movements. (University of Tokyo)
The 10 rats were fitted with miniature accelerometers that can measure even the slightest head movements. The study also involved 20 humans who wore accelerometers on headphones. One-minute excerpts from Mozart's K. 448 were played at four tempos of the original speed: 75 per cent, 100 per cent, 200 per cent and 400 per cent.
The original version is 132 beats per minute (bpm) and researchers discovered the rats found the tempo clearest within the 120 to 140 bpm range.
After seeing the success of the Mozart experiment, the rats got to enjoy other music, including Queen's ‘Another One Bites the Dust,’ Lady Gaga's ‘Born This Way,’ Michael Jackson's ‘Beat It’ and Maroon 5's ‘Sugar’.
According to researchers, both the rats and humans bopped their heads to a similar rhythm and "the level of head jerking decreased the more that the music was sped up."
“To the best of our knowledge, this is the first report on innate beat synchronization in animals that was not achieved through training or musical exposure,” said Takahashi.
Prior research says humans can predict upcoming beats in songs, but more studies are needed to confirm if rats can do this as well.
"I am also interested in how, why and what mechanisms of the brain create human cultural fields such as fine art, music, science, technology and religion,” Takahashi said. “I believe that this question is the key to understand how the brain works and develop the next-generation AI (artificial intelligence).”
Tue, 15 Nov 2022 04:28:00 -0600entext/htmlhttps://www.ctvnews.ca/sci-tech/rats-beat-it-to-the-music-just-like-humans-a-study-discovers-1.6153702Killexams : The data behind England’s race for World Cup glory
England’s World Cup 2022 players are running more than three kilometres more during games than their 1966 equivalents, and running more than twice as long at top speed, according to a study by STATSports that emphasises just how athletic the modern game has become.
The sports performance data company have been supplying the national team with technology including GPS training vests for over a decade, with Gareth Southgate leaning on them heavily for selection decisions.
STATSports undertook a study where their technology extensively analysed video footage of England’s 4-2 extra-time win over West Germany in the 1966 final.
It was found that Alan Ball had the highest total distance of any England player over the 120 minutes, with 8,550m covered. Phil Foden, one of his equivalents in the current team, by contrast covers an average of 10,620m per 90 minutes. The player who has the highest average total distance is Harry Kane, on 10,999m. Declan Rice however beat that by over a kilometre against Senegal, hitting 12,061m.
In less physically demanding positions, such as centre-half, Bobby Moore covered 7,996m across the two hours against Harry Maguire’s 10,888m in an average 90 minutes.
The gaps are even greater in high-speed running. Ball was also the player to run the fastest for the longest in 1966, at 614m, with that more than doubled by Raheem Sterling in 2022, at 1,331m.
Kane meanwhile runs more than double the distance at speed than his equivalent in Geoff Hurst. England’s 1966 hero covered 606m of high-speed running in that famous match, while Kane manages 1,223m now.
The point of the study isn’t to dismiss or be disrespectful towards the heroes of 1966, but merely because it is useful in showing how the game has physically transformed with the evolution of sports science.
For context, High Speed Running is the distance that covered over 5.5m/s (19.8km/h). STATSports say it tracks all those lung-bursting runs, overlaps on the wings or tracking back to help out teammates.
Professional players now can tally upwards of 1,100m of HSR during a game, depending on tactics and position played.â¯